Hi,
I graduated from Saint Leo University and I received a degree in Education from there. I am located locally so I took some of the more difficult classes on-campus, but I would have to say the difference between Saint Leo and other online schools is that I feel that it is more legit (since it is also a brick and mortar school), more affordable than other options, and they seem to have specific (i.e. different from brick and mortar) curriculum for online learning.
Some schools try to teach traditionally via online, and it doesn't quite work out that way. Hope this helps.